Amber Capone had become afraid of her husband. The “laid-back, bigger than life and cooler than cool” man she’d married had become isolated, disconnected and despondent during his 13 years as a U.S. Navy SEAL. Typically, he was gone 300 days of the year, but when he was home, Amber and their two children walked on eggshells around him. “Everyone was just playing nice until he left again,” Amber says.
In 2013, Marcus retired from the military. But life as a civilian only made his depression, anger, headaches, anxiety, alcoholism, impulsivity and violent dreams worse. Sometimes he’d get upset by noon and binge-drink for 12 hours. Amber watched in horror as his cognitive functioning declined; Marcus was in his late 30s, but he would get lost driving his daughter to volleyball, and sometimes he couldn’t even recognize his friends. Psychologists had diagnosed him with posttraumatic stress disorder (PTSD), depression and anxiety, but antidepressants, Ambien and Adderall didn’t help. He visited a handful of brain clinics across the country, which diagnosed him with postconcussive syndrome after a childhood of football—then a career punctuated by grenades, explosives, rifles and shoulder-fired rockets. But all they offered were more pills, none of which helped either.
Marcus wasn’t the only one suffering in his tight-knit community of Navy SEALs and special-operations veterans. A close friend killed himself, and Amber knew her husband could be next. “I truly thought that Marcus would be the one having the suicide funeral,” Amber says.
There was one last option.
One of Marcus’ retired Navy SEAL friends, who had similarly struggled, had traveled internationally to take ibogaine, a psychedelic drug illegal in the U.S. The ibogaine experience had been transformative for him, and he thought it might be the same for Marcus. “I thought it was crazy,” Marcus says. “How can you take another pill to solve all your problems?” But Amber begged him to try it, and Marcus gave in. On Veterans Day in 2017, Marcus checked into a treatment center in Mexico, popped an ibogaine pill, slipped on eyeshades and noise-canceling headphones, and went on his first-ever psychedelic trip. After an hour or so, he entered a waking dream state and watched a movie of his life play out before his eyes. It lasted 12 hours, and it was awful at times. “Imagine some of the worst experiences of your life,” Marcus says. “You’re going to experience these again.”
Life events flipped through his mind’s eye in rapid fire. Other times, painful memories slowed to a crawl. Marcus saw himself having conversations with his dead father, with buddies he’d lost to the wars over the years, with God. “You can’t hide from the medicine,” he says. “It’s just going to go down there and basically pull up any traumas, anything hiding in your subconscious that may be affecting you that you don’t even realize.”
When it was over, Marcus felt as if he’d finally put down a heavy load he’d been carrying for years. For the first time in a long time, he didn’t want a drink, and he didn’t touch alcohol for a year after. “I was thinking clear. I wasn’t impulsive anymore. I had no anxiety. I wasn’t depressed,” he says. Amber couldn’t believe it, but when she picked him up, she knew she had her husband back. “When he walked into the room, it was as though I was witnessing him the first time I met him,” she says. “His anger and his darkness and his whole demeanor had changed. All of that was gone. He was easy. He was light. He was present. He was happy. It just absolutely blew my mind.”

Retired Navy SEAL Marcus Capone and his wife Amber started a nonprofit to fund psychedelic treatment research for veterans
Brent Humphreys for TIME
Once dismissed as a fringe, counterculture vice, psychedelics are rapidly approaching acceptance in mainstream medicine. These drugs uniquely change the brain, and a person’s awareness of experiences, in the span of just a few hours. This fast-acting shift could be useful in mental-health treatments, and research is already supporting this notion. Just one dose of psilocybin, the active ingredient in magic mushrooms, was recently shown to ease depression and anxiety in cancer patients—an outcome that lasted for years after their trip. Researchers are recognizing that psychedelics can provide a radical new approach to mental-health treatments at a time when innovation is desperately needed.
For addiction in particular, the need has never been greater. More Americans died from drug overdoses last year than ever before, aggravated by the COVID-19 pandemic. Weekly counts of drug overdoses were up to 45% higher in 2020 than in the same periods in 2019, according to research from the U.S. Centers for Disease Control and Prevention published in February. Available treatments can’t meet the need. They aren’t effective for everyone, may require long-term adherence and are sometimes addictive themselves.
Ibogaine is one of the most promising psychedelics for addiction. Few people have heard of it, it’s illicit in the U.S., and nobody does it for fun. It’s not pleasant. It could kill you. But for extinguishing addiction—and a range of other issues—many people swear there’s nothing like it. The drug hails from a shrub called Tabernanthe iboga, which is native to Central