
Mithradites of Fond du Lac (2013) by got-any-grapes
On the way were still more beers, the night being young in Fond du Lac, Wisconsin, and Tim’s blood stanching where the cobra had bitten him. He wanded a good finger over the restaurant’s menu pictures and told me, “If it was you, dude, you’d be dead in this Applebee’s.”
If it was anyone else on this earth, they’d be dead. The African water cobra that had tagged him two hours earlier is so rare a specimen that no antivenom for it currently exists. Yet cobra bite and lagers notwithstanding, Tim looked fresh; he was well on his way to becoming the first documented survivor of that snake’s bite.

“Which reminds me,” he said from across the table, taking out his phone so I could snap a picture of his bloody hand. “For posterity. After tonight, every book is fucking wrong.”
It was on my account that he had done this, willfully accept the bite. Even though we’d only shaken hands that bright winter afternoon in the salted parking lot of a Days Inn. Tim Friede, the man from the internet who claimed to have made himself immune to the planet’s deadliest serpents. I’d come to test his mettle, to goad him into an unprecedented ordeal: five venomous snakebites in forty-eight hours.
Around us, young people were getting unwound in a hurry. The hour was fast approaching when the restaurant would flip off the apple portion of its lighted sign, clear out the tables and chairs, turn the edited jams to eleven, and allow for boner grinding on the floor space. Our server returned with the beers, and Tim looked up at her with his serous blue eyes, smiling, and said, “You never did card me. You have to guess.” She demurred. He continued: “I could be your dad.”
While Tim fumbled for an in with her, I considered the swollen hand he propped next to his head. Two streams of blood had rilled down and around his wristbone, reading like an open quote. He was a dad’s age, forty-four years old, but he appeared both strangely boyish and grizzled. He had an eager smile of small, square teeth. His hair was a platinum buzz. The skin over his face was bare and very taut; it looked sand-scoured, warm to the touch. Scar tissue and protuberant veins crosshatched his thin forearms, which he now covered by rolling down the sleeves of two dingy long-sleeve T-shirts. His neck was seamed from python teeth.
The snake that had done his twilight envenoming was Naja annulata, about six feet long and as thick as elbow pipe. She was banded in gold and black, a design not unlike that of the Miller Genuine Draft cans we’d bought and then housed on our way to Tim’s makeshift laboratory. When we walked in, the snake was shrugging smoothly along the walls of her four-by-two plastic tank. She was vermiform mercury. And she greeted us with a hiss, a sourceless, sort of circular sizzle, what one would hear if one suddenly found oneself in the center of a hot skillet. Kissing-distance past my reflection in the glass, the cobra induced a nightmare inertia of attraction and revulsion. She had not spirals but eclipses for eyes.
“I love watching death like this,” Tim had said, leaning in, startling me. “Some nights I watch them all night, like fish. Mesmerizing.”
The cobra was one of a $1,500 pair he’d just shipped in, Tim preferring to spend much of what he earns—working the 10 p.m.–to–6 a.m. line shift at Oshkosh Truck—on his snakes. The thing nosed under an overturned Tupperware container while I checked her CV on my phone. Her venom was a touch more potent than arsenic trisulfide. Tim unlatched the front of her tank, reached in, and was perforated before he knew it. The cobra flew at him with her mouth open and body lank, like a harpoon trailing rope.
“Ho ho, that’s just beautiful,” Tim said, withdrawing his hand. There were two broken fangs stapled into his ring finger.
He picked up a beer with his other hand, cracked it expertly with his pointer. I glanced around at all the other caged ampersands—mambas, vipers, rattlesnakes—and I smiled. Rosy constellations of Tim’s blood pipped onto the linoleum, shining brighter than old dead ones.
*
A little while ago, I was searching the web for the man who best embodied the dictum “That which does not kill me makes me stronger.” I was looking for someone who thought he’d succeeded in fortifying his inborn weaknesses, who believed he had bunged the holes left by God. I discovered Tim among the self-immunizers. They’re this community of a couple dozen white, Western males who systematically shoot up increasing doses of exotic venoms so as to inure their immune systems to the effects. Many of these men handle venomous snakes for business or pleasure, so there’s a practical benefit to their regimen. A few prefer instead to work their way from snakes to scorpions to spiders, voiding creatures’ power over them. Most seem to be autodidacts of the sort whose minds recoil at the notion of a limitation deliberately accepted—something I sympathized with, being myself an unfinished, trial creature. On their message boards, Tim talked the biggest medicine.
Their practice of self-immunization has a great old name: mithridatism. It comes from Mithradates VI of Pontus, a.k.a. “the Poison King.” In his lifetime, Mithradates was the last independent monarch to stand against Rome. He tried to unite Hellenic and Black Sea cultures into a neo-Alexandrian empire that could resist the Western one. For a moment, he was successful. Rome was forced to march against and to attempt to occupy the Middle East because of him. The Roman Senate declared him imperial enemy number one. A ruthless general was dispatched to search and destroy. Mithradates went uncaptured, hiding out in the craggy steppes.
Machiavelli deemed him a hero. Racine wrote him a tragedy. A fourteen-year-old Mozart composed an opera about him. A. E. Housman eulogized what was most remarkable about Mithradates:
They put arsenic in his meat
And stared aghast to watch him eat;
They poured strychnine in his cup
And shook to see him drink it up.

Like any despot, Mithradates inverted humanity’s basic psychic task and made insecurity less, not more, tolerable. He trusted no one, and in anticipation of conspiracy and betrayal, he bricked up his body into an impenetrable fortress. Each morning he took a personal cure-all tablet that included things like cinnamon, castor musk from beaver anuses, tannin, garlic, bits of poisonous skinks and salamanders, curdled milk, arsenic, rhubarb from the Volga, toxic honey, Saint-John’s-wort, the poison blood of pontic ducks, opium, and snake venom. His piecemeal inoculation worked so well that, when finally cornered, Mithradates was unable to poison himself. According to Appian’s Roman History, he begged his guard to murder him, saying, “Although I have kept watch and ward against all the poisons that one takes with his food, I have not provided against that domestic poison, always the most dangerous to kings, the treachery of army, children, and friends.”
The official recipe for his mithridatium was lost. But from Nero onward, every Roman emperor ingested a version of the Poison King’s antidote. Some had thirty-six ingredients, others as many as one hundred eighty-four. Charlemagne took it daily, as did Henry VIII and Elizabeth I. The Renaissance poor had their generic versions. Oliver Cromwell found it cleared his skin. London physicians prescribed it until 1786. You could buy it in Rome as recently as 1984. It was believed to kill the helplessness in your constitution. It’s the longest-lived panacea.
*
Tim is adopted. A cop raised him. Asked about his childhood, he offered: “I grew up fighting in the streets of inner-city Milwaukee.” He once tried to reach out to his biological parents after one of his children was born dead, strangled by the umbilical cord. “I thought it might be some kind of genetic thing,” he told me. “But I never found out. I couldn’t get an answer out of them as to why they didn’t want me.”
What he’d wanted for himself was to be a Marine, a Special Forces agent, but he broke his ankle in a car accident two months before basic training. He took a year off, re-enrolled in basic, re-broke the ankle. He could never be Special Forces if he couldn’t jump out of a plane, so he did the next best thing and became a high-rise window washer.
Ten years of window washing put him up to injecting snake venom. “Why?” He explained, “Because when you wake up feeling no pain, then you’ll know you’re dead.” He began by injecting a dilution of one part Egyptian cobra venom and ten thousand parts saline solution into his thigh, every week for a year. Then he upped the potency to one to one hundred, including in the mix Cape and monocled cobra venoms. From his journal of that time:
9-17-02
Small rise in fever, but started to eat and drink. No painkillers yet, but I’m barely hanging on. No one was allowed near me.
9-18 to 9-23-02
To sick to take notes, just don’t care.
9-24-02
This is the first day of puss release, thank God. 3:00 p.m., puss release with great pressure. Urine is clear, no painkillers, no antivenom, no hospital. 6:00 p.m., had second puss release. Couldn’t walk, needed to crawl.
He was left with a six-inch-by-six-inch scar on his leg and an immune system with twice as many venom-specific antibodies as most people have regular ones. He’s since repeated the procedure with mamba and rattlesnake venoms. He takes booster shots every couple of weeks, and he has begun immunizing against the inland taipan, the deadliest terrestrial snake. “There’s no standardized guide to this shit. Everybody’s different.
I sort of wrote the handbook on self-immunization,” Tim said, referring to a self-published PDF available on his website for twelve dollars.
“I’m separated from my wife of fifteen years because of this. I didn’t change oil or cut grass or really be a husband or father. I was researching venom twenty hours a day. I had
a thirteen-hundred-dollar mortgage. One day I came home and my wife had taken the kids, and she had left.” With her, he’s maintained a kind of relationship; it’s his kids, Tim admitted, that he’s lost touch with. “My wife was supportive, but I never needed her. Oh, she’d said, ‘The snakes or me’ before I lost our house. I was sleeping in a tent. My two kids are fifteen and six. But self-immunization is my entire life.”
*
Snake venom is this cocktail of ribonucleases, nucleotides, amino acid oxidases, and so on that, once injected into prey through hollow fangs, immediately goes to work disrupting cellular function. It breaks down tissue proteins, attacks muscles and nerves, dissolves intercellular material, and causes metabolic collapse. The stuff is usually classified as either neurotoxic (if it attacks the nervous system) or hemotoxic (if it goes for blood components), because even though most induce both neuro- and hemotoxic symptoms, each venom tends to induce more of one kind than the other. Meaning, the damage a venom does is species-specific. Snakebite is thus like lovesickness in that each time, you’re wrecked special and anew.
But there are generalities within the two categories. For instance: a potent, primarily neurotoxic venom will effect a quick death. Immediately after the bite, though, comes a lightness of being. Then an acute sense of hearing, almost painfully acute. Chest and stomach cramps next. Sore jaw. Tongue like a bed of needles. Inflamed eyes; lids closing involuntarily. The soles of your feet feel as if they’re on coals. Numb throat. Blurred vision. Then every fiber explodes in pain. From head to toe you are under a barrage of agonizing spasms. Head, neck, eyes, chest, limbs, teeth—searing, aching. The pain feels like a filament burning brightest before it pops. Then your vision splits. Everything splits. Then your muscle contractions are disabled. Your body paralyzes gradually and methodically, as though someone were going from room to room, turning out your lights. Your central nervous system is not able to tell your diaphragm to breathe. You fall down the tiers of a sleep that feels just and due, a reward.
In North America, only a few snakes—corals, elapids, and Mojave rattlers—are neurotoxic like the old-world killers, the cobras and mambas. The vast majority of venomous snakes here—the copperheads, the water moccasins, and the rattlers—are hemotoxic. Though their bites are less likely to kill, their venom, even if survived, often causes chunks of tissue or whole limbs to fall away. It dissolves you. But first you feel a flame bud and lick at the wound. Your skin tickles, pricks, and burns, as if in the process of crisping. Your lymph nodes distend and your neck balloons into a froggish sac. The venom is going from door to cellular door, pillaging. Blood from ruptured vessels escapes into your tissues. Your afflicted limb swells, hemorrhages, and enlarges to monstrosity. You sweat and go dumb. Your blood pressure plummets like a barometer before a storm. You see double, go into shock, and barf up everything. It then feels as if red-hot tongs have plunged inside you, to seek out the root of the pain. This is a living death. You witness yourself becoming a corpse piece by piece. You are barely able to piss, and what does come out is ruby red. You twitch and convulse. Your respiratory system is no longer strong enough to pump the bilge from your lungs. The foam you cough up is pink. And hours to days later, cardinal threads fall from your gums and eyes until, beaten by suffering and anguish, you lose your sense of reality. A chill of death invades your being. Your blood is thin as water. If you die, you die of a bleeding heart.
None of the above, I sh